Methane → HCID 12838137, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 20 g of 1-{3-[4-(3-methoxycarbonyl-propionamido)-2-methoxyphenoxy]-n-propyl}-4-phenyl-piperazine and 2 ml of xylene is stirred at 150° C. for 20 hours. Then, chloroform is added to the reaction mixture, and said mixture is treated with activated charcoal and then evaporated under reduced pressure to remove the solvent. The residue is purified by silica gel chromatography (Solvent: 1% methanol/chloroform), and then recrystallized from ethyl acetate. 910 mg of 1-[3-(4-succinimido-2-methoxyphenoxy)-n-propyl]-4-phenyl-piperazine are obtained as colorless needles. Yield: 54%

Provenance & Evidence