1H-1,2,4-Triazole → 58905-18-3

HRID 1648855Notes

Reaction equation

HRID 1648855 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.[Na].N1C=NC=N1.[OH-:12].[Na+].O[C:15]1([Cl:25])[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][CH:16]1[CH2:17][CH2:18]Cl>O.CS(C)=O>[OH:12][CH:17]([C:16]1[CH:20]=[CH:21][C:22]([Cl:24])=[CH:23][C:15]=1[Cl:25])[CH2:18][N:1]1[CH:5]=[N:4][CH:3]=[N:2]1

Participants

7

Reactant 4

HCID 92571H-1,2,4-TriazoleHCID 14798Sodium HydroxideHCID 204809262-Hydroxy-2,4-dichlorophenethyl chlorideHCID 454898221h-1,2,4-Triazole sodium salt

Product 1

HCID 66285758905-18-3

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

To a dimethyl sulfoxide solution (50 ml) of sodium 1,2,4-triazole, generated from 3.25 g (0.047 m) of 1H-1,2,4-triazole, and 1.9 g (0.047 m) of sodium hydroxide, is added 10 g (0.045 m) of 2-hydroxy-2,4-dichlorophenethyl chloride dropwise at 110° under nitrogen. The reaction is stirred at 110° for 11/2 hours. The reaction mixture is poured into water and extracted with methylene chloride. The combined organic extracts are washed with water and dried over MgSO4. Solvent is evaporated to give 8 g of product.

Workup

  1. extractionextracted with methylene chloride
  2. washThe combined organic extracts are washed with water
  3. dry with materialdried over MgSO4
  4. customSolvent is evaporated

Sources & evidence

ORD record
ord-40fae1094b9f41868e6eb81d226888d2
Source dataset
uspto-grants-1983_11
Patent number
US04414210

Reaction notes

Loading…