p-Toluenesulfonic acid → HCID 13236902, compound

Participants

Reaction Steps

A mixture of 1.5 g (0.007 m) of 2-hydroxy-2,4-dichlorophenethyl amine, 1.5 g (0.01 m) of N,N-dimethylformamide azine, 0.5 g of toluene p-sulfonic acid in 50 ml of toluene is heated under reflux overnight. Solvent is evaporated under reduced pressure. The residue is taken up in methylene chloride and the free base is purified by converting it to its hydrochloride salt and back neutralized with ammonium hydroxide solution to give 1.5 g of product.

Provenance & Evidence