Sodium Iodide → HCID 13151547, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.0 g of 2-bromomethyl-4-phenyltetrahydrofuran, 3.83 g of 1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, 2.48 g of sodium iodide and 2.3 g of potassium carbonate in 50 ml of dimethylformamide is heated with stirring at 60° C. for 24 hours. The reaction mixture is then poured into 200 ml of water, and 50 ml of ethyl acetate is added thereto. The mixture is stirred under ice-cooling. The crystals precipitated are collected by filtration, treated with maleic acid and recrystallized from ethanol to give 8-(4-phenyl-tetrahydro-2-furylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one maleate, melting at 202°-204° C. with decomposition.

Provenance & Evidence