Acetic Acid → HCID 178450359, compound

HRID 1648877Notes

Reaction equation

HRID 1648877 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([NH2:13])[O:10][N:9]=1.[OH-].[K+].C(O)(=O)C.[CH2:20](O)[CH2:21][CH2:22][CH3:23]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[N:12]=[C:11]([O:10][CH2:20][CH2:21][CH2:22][CH3:23])[NH:13][N:9]=1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 2631-ButanolHCID 14797Potassium Hydroxide2×HCID 204812101225851-81-9

Product 1

HCID 178450359HCID 178450359, compound

Procedure

To the product of Example 36, stage (a), (9.7 g) in n-butanol (110 ml) was added potassium hydroxide (9.7 g), and the mixture was refluxed for 4 hours. It was then cooled, and excess potassium hydroxide was neutralised with acetic acid. The mixture was then evaporated to give 12.2 g of desired product.

Workup

  1. temperaturethe mixture was refluxed for 4 hours
  2. temperatureIt was then cooled
  3. customThe mixture was then evaporated

Sources & evidence

ORD record
ord-b4a9d22cb5d2476ca635b8a2458eec0a
Source dataset
uspto-grants-1983_11
Patent number
US04414221

Reaction notes

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