反应详情

2-Chlorobenzoyl chloride (2.6 g) was dissolved in dioxan (90 ml) and 2-chlorobenzamidoxime (2.5 g) was added with stirring, followed by boron trifluoride etherate (0.2 ml). The solution was heated at reflux for 18 hours and was run down. The product was taken up in dichloromethane, and the solution was washed successively with saturated aqueous sodium bicarbonate, water, and saturated sodium chloride solution. It was then dried over magnesium sulphate, run down and recrystallised from ethanol to yield 2.3 g of desired product, mp 91°-92° C.

1. temperatureThe solution was heated
2. temperatureat reflux for 18 hours
3. washthe solution was washed successively with saturated aqueous sodium bicarbonate, water, and saturated sodium chloride solution
4. dry with materialIt was then dried over magnesium sulphate
5. customrecrystallised from ethanol