3-(4-Methoxyphenyl)propan-1-amine → HCID 20481274, compound

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Reaction Steps

Using 50 g of p-methoxyphenylpropylamine for the starting material of Example 1 gives 4-(3-aminopropyl)-7-methoxy-2(3H)-indolone hydrochloride. This material (3 g) was converted to the base and alkylated using methyl formate-formaldehyde at reflux to give 4-(3-dimethylaminopropyl)-7-methoxy-2(3H)-indolone hydrochloride and, after treatment with boron tribromide in methylene chloride at -20°, 4-(3-dimethylaminopropyl)-7-hydroxy-2(3H)-indolone hydrobromide.

Provenance & Evidence