2-Aminopyridine → HCID 70518469, compound

Participants

Reaction Steps

8-Chloro-6-(α-bromopropionyl)-3,4-dihydrocarbostyril (4 g), 2-aminopyridine (3.57 g) and acetonitrile (20 ml) were refluxed for 3 hours. The reaction mixture was concentrated to dryness and the residue (oily product) was washed with water. Then, the residue was dissolved in acetone and 48% hydrobromic acid was added to the solution to adjust pH to about 1 and crystals which formed were crystallized by filtration. The crude crystals thus obtained were recrystallized from water to give 2.74 g of 8-chloro-6-(3-methylimidazo[1,2-a]-pyridine-2-yl)-3,4-dihydrocarbostyril monohydrobromide hemihydrate.

Provenance & Evidence