2-Amino-4-methylpyridine → HCID 13260242, compound

Participants

Reaction Steps

5-Chloroacetyl-8-methoxycarbostyril (5 g), 2-amino-4-picoline (6.45 g) and acetonitrile (40 ml) were reacted with refluxing for 3 hours, and the reaction mixture was cooled with ice water. Crystals which formed were collected by filtration. The crystals were suspended in acetone-methanol and the suspension was adjusted to pH of about 1 by the addition of concentrated hydrochloric acid. Crystals which formed were collected by filtration and recrystallized from methanol to give 4.0 g of 5-(7-methylimidazo[1,2-a]pyridine-2-yl)-8-methoxycarbostyril monohydrochloride 3/2 hydrate.

Provenance & Evidence