Hydrogen Bromide → HCID 20481484, compound

Participants

Reaction Steps

To a solution of 5-(imidazo[1,2-a]pyridine-2-yl)-8-methoxycarbostyril (4 g) in acetic acid (80 ml) was added dropwise at room temperature a solution of bromine (2.22 g) in acetic acid (5 ml). After completion of addition, the mixture was stirred for 3 hours. Crystals which precipitated were collected by filtration and washed with diethyl ether. The crystals thus obtained were dissolved in acetone and the solution was adjusted to pH of about 1 by the addition of 48% hydrobromic acid. Crystals which precipitated were collected by filtration and recrystallized from methanol-water to give 5 g of 5-(3-bromoimidazo[1,2-a]pyridine-2-yl)-8-methoxycarbostyril monohydrobromide monohydrate.

Provenance & Evidence