5-Propyl-1,3-thiazol-2-amine → 2-(2,2-Dicarbethoxyethenylamino)-4-ethyl-5-methylthiazole

HRID 1649036Notes

Reaction equation

HRID 1649036 reaction equation
NC1SC=C(CCCCC)N=1.[NH2:12][C:13]1[S:14][C:15]([CH2:21]C)=[C:16]([CH2:18][CH2:19]C)[N:17]=1.NC1SC(C(C)C)=C(C(C)C)N=1.NC1SC(CCC)=CN=1.NC1SC(C(C)C)=CN=1.NC1SC(CCCCC)=CN=1.[C:64]([C:69]([C:77]([O:79][CH2:80][CH3:81])=[O:78])=[CH:70]NC1SC=CN=1)([O:66][CH2:67][CH3:68])=[O:65]>>[C:77]([C:69]([C:64]([O:66][CH2:67][CH3:68])=[O:65])=[CH:70][NH:12][C:13]1[S:14][C:15]([CH3:21])=[C:16]([CH2:18][CH3:19])[N:17]=1)([O:79][CH2:80][CH3:81])=[O:78]

Participants

8

Reactant 7

HCID 32822365-Propyl-1,3-thiazol-2-amineHCID 43665772-Amino-5-pentylthiazoleHCID 64851875-Ethyl-4-propyl-1,3-thiazol-2-amineHCID 104869545-(Propan-2-yl)-1,3-thiazol-2-amineHCID 13281138Diethyl {[(1,3-thiazol-2-yl)amino]methylidene}propanedioateHCID 133294812-Amino-4-pentylthiazoleHCID 202712142-Amino-4,5-diisopropylthiazole

Product 1

HCID 132533572-(2,2-Dicarbethoxyethenylamino)-4-ethyl-5-methylthiazole

Procedure

By the same method, 2-amino-4-pentylthiazole, 2-amino-4-propyl-5-ethylthiazole, 2-amino-4,5-diisopropylthiazole, 2-amino-5-propylthiazole, 2-amino-5-isopropylthiazole, 2-amino-5-pentylthiazole, 2-amino-6-phenylcyclopentenothiazole, 2-amino-5,7-dimethylcyclohexenothiazole, 2-amino-4,6,6-trimethylcyclopentenothiazole, and 2-amino-7-methylcyclooctenothiazole are converted to the corresponding 2-(2,2-dicarbethoxyethenylamino)thiazole derivatives.

Sources & evidence

ORD record
ord-8d8fb89b440c425488f17aca78d1bb9b
Source dataset
uspto-grants-1983_11
Patent number
US04414388

Reaction notes

Loading…