HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Phenyl Isothiocyanate | HCID 7673 | — |
| Reactant | 3-Methyl-1,3-thiazolidin-2-imine | HCID 77318 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-(3-Methyl-1,3-thiazolidin-2-ylidene)-N'-phenylthiourea | HCID 54546998 | 75% |
Reaction Steps
A solution of 0.043 mole of 2-imino-3-methylthiazolidine and an equimolar amount of phenylisothiocyanate in 70 ml of dry benzene is refluxed under nitrogen for 2.5 hours. Some ether is added to the cooled reaction mixture and solids are filtered off, 9.8 g (90%). Recrystallization from acetonitrile-ether (1:1) gives 8.0 g (75%) of pure N-(3-methyl-2-thiazolidinylidene)-N'-phenylthiourea; m.p. 168.5°-170.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04414211 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-48d0ad4196374bd6a78daf7039b1f5b7 |
| Source note | uspto-grants-1983_11 |