tert-Butanol → HCID 131713221, compound

Participants

Reaction Steps

A solution of 2.19 g (0.01 mole) of N'-(4-methylphenyl)-4-morpholinecarboximidamide and 2.85 g (0.0104 moles) of 3-methyl-2-methylthio-2-thiazolinium iodide (prepared by the method of J. W. Batty and B. C. L. Weedon, J. Chem. Soc., 786 (1949) was heated under reflux in 25 ml of tert-butanol for 1.5 hours. Upon cooling, a white crystalline solid separated, and was recrystallized twice from ethanol-ether to afford 3.00 g (67%) of N'-(4-methylphenyl)-N-(3-methyl-2-thiazolidinylidene-4-morpholinecarboximidamide monohydroiodide as a white solid homogeneous on TLC, m.p. (175) 186°-188° C. Anal. Calcd. for C16H22N4OS.HI (318.44/462.76): C, 43.06; H, 5.19; N, 12.55. Found: C, 43.05; H, 5.21; N, 12.56.

Provenance & Evidence