Penicillin G → L-Penicillamine

HRID 1649059Notes

Reaction equation

HRID 1649059 reaction equation
[OH-].[Na+].[CH3:3][C:4]1([CH3:25])[S:8][C@@H]2[C@H](NC(CC3C=CC=CC=3)=O)C(=O)[N:6]2[C@H:5]1[C:22]([OH:24])=[O:23]>O>[NH2:6][C@H:5]([C:22]([OH:24])=[O:23])[C:4]([SH:8])([CH3:25])[CH3:3]

Participants

4

Reactant 2

HCID 5904Penicillin GHCID 14798Sodium Hydroxide

Product 1

HCID 92863L-Penicillamine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-(2-aminoethyl) carbamylmethylated cellulose was prepared in the manner set forth in Example 1. The amino ethyl derivative was kept at a concentration of 6.5 mg/ml in aqueous solution. Three ml of this solution were diluted to 6 ml with distilled water. The pH was adjusted to 9 with 0.1 N NaOH. One hundred mg of Penicillin G (sodium salt, Sigma Chemicals, St. Louis, U.S.A.) were added at once, and the resulting solution left overnight at room temperature. The solution was then dialyzed in the cold against two daily changes of 2 liters of water for 3 days. The CMC-Pen conjugate thus formed was kept in solution in the cold.

Workup

  1. customwas prepared in the manner
  2. customThe solution was then dialyzed in the cold against two daily changes of 2 liters of water for 3 days

Sources & evidence

ORD record
ord-7e3866c4ce434d96a2826866c9c511a0
Source dataset
uspto-grants-1983_11
Patent number
US04415552

Reaction notes

Loading…