Isopropyl chloroformate → HCID 12805011, compound

Participants

Reaction Steps

6.0 g (29.5 millimoles) of 6-(p-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone, 4.0 g (32.6 millimoles) of isopropyl chloroformate and 100 ml of absolute toluene are refluxed for 16 hours. The product is filtered off at 10° C., washed first with toluene and then with water, and recrystallized twice from dimethylformamide/water. 4.3 g (50% of theory) of 4,5-dihydro-6-(p-isopropoxycarbonylaminophenyl)-5-methyl-3(2H)-pyridazinone are obtained as colorless crystals, of melting point 236°-237° C.

Provenance & Evidence