HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 1-[alpha-(2-Hydroxyethoxy)-4-methoxybenzyl]-5-fluorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | 4-Methoxybenzaldehyde | HCID 31244 | — |
| Reactant | 2-(p-Methoxyphenyl)-1,3-dioxolane | HCID 221627 | — |
| Reactant | HCID 68585259 | HCID 68585259 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 1-[alpha-(2-Hydroxyethoxy)-4-methoxybenzyl]-5-fluorouracil | HCID 13057129 | — |
Reaction Steps
Bis-trimethylsilyl-5-fluorouracil prepared from 5-fluorouracil (10 g) as in Example 1 was reacted with 2-(4-methoxyphenyl)-1,3-dioxolan prepared from p-methoxybenzaldehyde and ethylene glycol, and treated as in Example 8 to give 6.5 g of crystalline 1-[α-(2-hydroxyethoxy)-4-methoxybenzyl]-5-fluorouracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415573 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-468deeef74404d3f854797d6f42e81a0 |
| Source note | uspto-grants-1983_11 |