HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 1-[alpha-(2-Hydroxyethoxy)-3,4,5-trimethoxybenzyl]-5-fluorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | 3,4,5-Trimethoxybenzaldehyde | HCID 6858 | — |
| Reactant | 2-(3,4,5-Trimethoxyphenyl)-1,3-dioxolane | HCID 13124196 | — |
| Reactant | HCID 68585259 | HCID 68585259 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[alpha-(2-Hydroxyethoxy)-3,4,5-trimethoxybenzyl]-5-fluorouracil | HCID 15583556 | — |
Reaction Steps
2-(3,4,5-Trimethoxyphenyl)-1,3-dioxolan (20.3 g) prepared from 3,4,5-trimethoxybenzaldehyde and ethylene glycol was dissolved in dichloromethane (50 ml). To the solution bis(trimethylsilyl)-5-fluorouracil prepared from 5-fluorouracil (10 g) was added and treated as in Example 10 to give 7.2 g of crystalline 1-[α-(2-hydroxyethoxy)-3,4,5-trimethoxybenzyl]-5-fluorouracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415573 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-29b421abb45d414cbb44ab7d76d30dcb |
| Source note | uspto-grants-1983_11 |