HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Fluorouracil → 1-[alpha-(2-Acetoxyethoxy)-2-ethoxybenzyl]-5-fluorouracil
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Fluorouracil | HCID 3385 | — |
| Reactant | Benzaldehyde, 2-ethoxy- | HCID 11950 | — |
| Reactant | 2-(2-Ethoxyphenyl)-1,3-dioxolan | HCID 20480605 | — |
| Reactant | HCID 68585259 | HCID 68585259 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[alpha-(2-Acetoxyethoxy)-2-ethoxybenzyl]-5-fluorouracil | HCID 13236256 | — |
Reaction Steps
Bis(trimethylsilyl)5-fluorouracil prepared as in Example 1 from 5-fluorouracil (10 g), and 2-(2-ethoxyphenyl)-1,3-dioxolan (15 g) prepared from 2-ethoxybenzaldehyde and ethylene glycol were dissolved in dichloromethane (50 ml). The mixture was treated and acetylated as in Example 10 to give 6.2 g of crystalline 1-[α-(2-acetoxyethoxy)-2-ethoxybenzyl]-5-fluorouracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415573 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-0fbd983164ec4a8a89ca6591addee897 |
| Source note | uspto-grants-1983_11 |