反应详情

Bis(trimethylsilyl)-5-fluorouracil prepared from 5-fluorouracil (10 g), and 2-2,6-dichlorophenyl-1,3-dioxolan (32.0 g) which had been prepared from 2,6-dichlorobenzaldehyde and ethylene glycol were subjected to reaction as in Example 10. Following adding chloroform (100 ml), the reaction mixture was washed twice with a cold saturated NaCl aqueous solution, and then aqueous sodium bicarbonate, and water, and dried over anhydrous magnesium sulfate. The solvent was evaporated off and the residue was purified by column chromatography using silica gel and acetone-chloroform (1:4) as an eluant to give 6.9 g of crystalline 1-[α-(2-hydroxyethoxy)-2,6-dichlorobenzyl]-5-fluorouracil.

1. customwere subjected to reaction as in Example 10
2. washthe reaction mixture was washed twice with a cold saturated NaCl aqueous solution
3. dry with materialaqueous sodium bicarbonate, and water, and dried over anhydrous magnesium sulfate
4. customThe solvent was evaporated off
5. customthe residue was purified by column chromatography