反应详情

4.5 gm (0.0264 mol) of 2-methylthio-5-nitro-pyridine were hydrogenated at 50° C. and 5 bars pressure in ethanol in the presence of Raney nickel as the catalyst. After the catalyst had been filtered off and after evaporation of the filtrate in vacuo an oil was obtained. A solution of 6.84 gm (0.032 mol) of the sodium monohydrate salt of 2-chloro-4-hydroxy-5-nitro pyrimidine in 150 ml of water was added to the solution of this oil in water. The aqueous solution was heated for 30 minutes on a steam bath, and the resulting precipitate suction-filtered off, washed with water and dried. 4-Hydroxy-2-(6'-methylmercapto-3-pyridyl)amino-5-nitro-pyrimidine was obtained.

1. customwere hydrogenated at 50° C.
2. filtrationAfter the catalyst had been filtered off
3. customafter evaporation of the filtrate in vacuo an oil
4. customwas obtained
5. temperatureThe aqueous solution was heated for 30 minutes on a steam bath
6. filtrationthe resulting precipitate suction-filtered off
7. washwashed with water
8. customdried