反应详情

2-Amino-5-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]cinnamic acid (5 g) was dissolved in a mixed solvent consisting of ethanol and water. After adding 5% palladium-carbon (0.5 g), the mixture was reduced at atmospheric pressure of hydrogen gas. After absorption of theoretical amount of hydrogen gas, the catalyst was removed by filtration and the ethanol-water phase was concentrated to dryness. The residue was dissolved in chloroform and separated through silica gel column chromatography to give 1.5 g of 3-{2-amino- 5-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]phenyl}-propionic acid, m.p. 98°-101° C.

1. customAfter absorption of theoretical amount of hydrogen gas
2. customthe catalyst was removed by filtration
3. concentrationthe ethanol-water phase was concentrated to dryness
4. dissolutionThe residue was dissolved in chloroform
5. customseparated through silica gel column chromatography