反应详情

A mixture of 9.36 g of 6-amino-3,4-dihydrocarbostyril, 18 g of bis(β-bromoethyl)amine monohydrobromide and 70 ml of methanol was refluxed for 15 hours while stirring. After cooling, 3.06 g of sodium carbonate was added and the resulting mixture was refluxed for 8 hours while stirring. The reaction mixture was cooled to precipitate crystals which then were collected by filtration, the crystals were washed with methanol to give 9.1 g of 6-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide, m.p. 289°-293° C. (decomp.) (methanol-water), colorless needles.

1. temperaturewas refluxed for 15 hours
2. temperatureAfter cooling
3. temperaturethe resulting mixture was refluxed for 8 hours
4. stirringwhile stirring
5. temperatureThe reaction mixture was cooled
6. customto precipitate crystals which
7. filtrationthen were collected by filtration
8. washthe crystals were washed with methanol