Dimethyl Sulfoxide → HCID 13236318, compound

Participants

Reaction Steps

6-(1-Piperazinyl)-3,4-dihydrocarbostyril (2.6 g) and 2.34 ml of triethylamine was added to 40 ml of dimethyl sulfoxide and the mixture was stirred at room temperature while slowly adding dropwise 10 ml of dimethyl sulfoxide solution containing 3.3 g of 3,5-dinitrobenzoyl chloride. After completion of addition the reaction mixture was stirred at room temperature for 30 minutes. The reaction mixture was poured into a large amount of water and extracted with chloroform. The extract was washed with saturated sodium hydrogencarbonate solution and subsequently with water and dried over anhydrous sodium sulfate, chloroform was distilled off and residual crystals were recrystallized from methanol-chloroform to give 0.3 g of 6-[4-(3,5-dinitrobenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 262°-264° C., reddish black needles.

Provenance & Evidence