HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 13243490, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1-Chloro-4-(chloromethyl)benzene | HCID 7723 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one | HCID 11117896 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 13243490 | HCID 13243490 | 32.5% |
Reaction Steps
To a mixture of 1.0 g of 6-(1-piperazinyl)-3,4-dihydrocarbostyril, 1.11 g of potassium carbonate and 20 ml of DMF was added 780 mg of 4-chlorobenzyl chloride and the mixture was stirred at 70°-80° C. for 4 hours. The reaction mixture was poured into a large amount of water and extracted with chloroform. Chloroform was distilled off and the residue was purified through silica gel column chromatography. Recrystallization from chloroform-methanol gave 500 mg of 6-[4-(4-chlorobenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 190°-191.5° C., colorless needles.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415572 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-6b0d1980fe394422b1d0cb78e75b9f25 |
| Source note | uspto-grants-1983_11 |