反应详情

To a mixture of 1.2 g of 5-(1-piperazinyl)-3,4-dihydrocarbostyril, 1.17 g of potassium carbonate and 20 ml of DMF was added 895 mg of 3,4-dichlorobenzyl chloride and the mixture was stirred at 60°-70° C. for 3 hours. The reaction mixture was poured into a large amount of water and extracted with chloroform. After washing with water the extract was dried over anhydrous sodium sulfate. Chloroform was distilled off and the residue was purified through silica gel column chromatography. After conversion to hydrochloric acid salt with methanol-hydrochloric acid the product was recrystallized from methanol to give 0.17 g of 5-[4-(3,4-dichlorobenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril monohydrochloride monohydrate, m.p. 298.5°-300° C. (decomp.), colorless granules.

1. extractionextracted with chloroform
2. washAfter washing with water the extract
3. dry with materialwas dried over anhydrous sodium sulfate
4. distillationChloroform was distilled off
5. customthe residue was purified through silica gel column chromatography
6. customAfter conversion to hydrochloric acid salt with methanol-hydrochloric acid the product was recrystallized from methanol