Potassium Carbonate → HCID 20480600, compound

Participants

Reaction Steps

To a mixture of 1.2 g of 5-(1-piperazinyl)-3,4-dihydrocarbostyril, 1.17 g of potassium carbonate and 50 ml of benzene was added 688 mg of 4-cyanobenzyl chloride and the mixture was stirred under reflux for 3 hours. The reaction mixture was poured into a large amount of saturated saline solution and extracted with chloroform. After washing with water, the extract was dried over anhydrous sodium sulfate. Chloroform was distilled off and the residue was purified through silica gel column chromatography to give 105 mg of 5-[4-(4-cyanobenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril.

Provenance & Evidence