1,3-Benzodioxole, 5-(chloromethyl)- → HCID 20480565, compound

Participants

Reaction Steps

To a mixture of 1.2 g of 6-(1-piperazinyl)-3,4-dihydrocarbostyril, 1.17 g of potassium bicarbonate and 20 ml of DMF was added 785 mg of 3,4-methylenedioxybenzyl chloride and the mixture was stirred at 80°-90° C. for 3.5 hours. The reaction mixture was poured into a large amount of saturated saline solution and extracted with chloroform. After washing with water the extract was dried over anhydrous sodium sulfate. Chloroform was distilled off and the residue was purified through silica gel column chromatography to give 0.2 g of 6-[4-(3,4-methylenedioxybenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril.

Provenance & Evidence