Trimethylamine → HCID 13236331, compound

Participants

Reaction Steps

5-(1-Piperazinyl)-3,4-dihydrocarbostyril (1.0 g) was added to a mixture of 10 ml of DMF and 0.85 ml of trimethylamine and the mixture was stirred at room temperature while slowly adding dropwise 5 ml of DMF solution containing 1.07 g of p-toluenesulfonyl chloride. After completion of addition, the reaction mixture was stirred at the same temperature as above for 30 minutes. The reaction mixture was poured into a large amount of saturated saline solution and extracted with chloroform. The extract was washed with water and dried over anhydrous sodium sulfate. Chloroform was distilled off and residual crystals were recrystallized from DMF to give 800 mg of 5-[4-(p-toluenesulfonyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 302°-304° C., colorless powders.

Provenance & Evidence