Allyl chloride → HCID 70536330, compound

Participants

Reaction Steps

5-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (1.96 g) and 0.20 g of sodium amide were mixed with 60 ml of DMF and stirred at room temperature for 2 hours. Then, to the mixture was added 0.67 g of allyl chloride and the mixture was stirred at room temperature for 10 hours. The reaction mixture was poured into 150 ml of saturated saline solution and organic substances were extracted with chloroform. The chloroform layer was washed with water and dehydrated. Chloroform was distilled off and the residue was purified through silica gel column chromatography followed by recrystallization from methanol-ether to give 1.76 g of 1-allyl-5-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril hemihydrate, m.p. 120°-122° C., colorless granules.

Provenance & Evidence