Sodium Carbonate → HCID 13236307, compound

Participants

Reaction Steps

A mixture of 14.5 g of 6-[bis(2-chloroethyl)amino]-3,4-dihydrocarbostyril, 8.0 g of 4-methoxybenzylamine and 70 ml of methanol was stirred under reflux for 15 hours. After cooling, to the reaction mixture was added 3.06 g of sodium carbonate and the reaction mixture was stirred under reflux for 8 hours. After cooling, crystals which precipitated were collected by filtration and recrystallized from ethanol to give 8.1 g of 6-[4-(4-methoxybenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 196°-198° C., colorless needles.

Provenance & Evidence