Phosphoric Acid → HCID 13236307, compound

Participants

Reaction Steps

A mixture of 9 g of 6-[bis(2-hydroxyethyl)amino]-3,4-dihydrocarbostyril, 4.1 g of 4-methoxybenzylamine and 7.6 g of polyphosphoric acid prepared from 3.8 g of phosphorus pentoxide and 3.8 g of phosphoric acid was reacted at 160° to 170° C. for about 6 hours. After allowing to cool, to the reaction mixture was added dropwise about 500 ml of water to dissolve. The solution was neutralized with an aqueous 48% sodium hydroxide solution and extracted with chloroform. After drying the extract over potassium carbonate, chloroform was distilled off. Recrystallization of the residue from ethanol gave 8 g of 6-[4-(4-methoxybenzyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 196°-198° C., colorless needles.

Provenance & Evidence