HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N-(beta-bromopropionyl)-p-piperazinylaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethanamine, 2-bromo-N-(2-bromoethyl)-, hydrobromide (1:1) | HCID 12692731 | — |
| Reactant | N-(beta-bromopropionyl)-p-aminoaniline | HCID 20480582 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(beta-bromopropionyl)-p-piperazinylaniline | HCID 20480598 | 29.5% |
Reaction Steps
A mixture of 14.0 g of N-(β-bromopropionyl)-p-aminoaniline, 18 g of bis(β-bromoethyl)amine monohydrobromide and 70 ml of methanol was stirred under reflux for 15 hours. After cooling, the reaction mixture was added 3.06 g of potassium carbonate and stirred under reflux for 8 hours. After cooling, crystals which formed were collected by filtration and washed with methanol to give 5.3 g of N-(β-bromopropionyl)-p-piperazinylaniline. Production of the compound was confirmed by IR and NMR spectra.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04415572 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-f96b17fad8cb4d7e98fb24daffbb71a7 |
| Source note | uspto-grants-1983_11 |