Sodium Hydroxide → HCID 13236306, compound

Participants

Reaction Steps

N-(β-methoxyacryloyl)-p-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]aniline (5 g) was added portionwise to 50 ml of 60% H2SO4 while stirring at room temperature. After continuing the reaction for 2 hours, the reaction mixture was neutralized with 10 N NaOH to precipitate crystals which then were collected by filtration and washed with water. Recrystallization of the crystals from chloroform-methanol gave 230 mg of 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]carbostyril, m.p. 265°-266.5° C. (decomp.), yellow granules.

Provenance & Evidence