Sodium Carbonate → HCID 20480595, compound

Participants

Reaction Steps

A mixture of 23 g of 7-amino-3,4-dihydrocarbostyril, 48 g of bis(β-bromoethyl)amine hydrobromide and 200 ml of methanol was refluxed with stirring for 8 hours. After cooling to room temperature, 7.52 g of sodium carbonate was added to the mixture followed by refluxing while stirring for additional 8 hours. After distilling off methanol under reduced pressure, isopropanol was added to the residue. After cooling, crystals which precipitated were collected by filtration and recrystallized from ethanol 3 times to give 15 g of 7-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide, m.p. 174°-177° C., colorless granules.

Provenance & Evidence