Water → HCID 13236393, compound

Participants

Reaction Steps

To a solution of 800 mg of 7-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide in 10 ml of DMF was added 1.2 ml of triethylamine, and then a solution of 730 mg of 4-chlorobenzoyl chloride in 2 ml of DMF was added dropwise to the mixture while stirring. After completion of addition, the mixture was stirred at room temperature for 30 minutes. The reaction mixture was poured into a large amount of water. Crystals which formed were collected by filtration, washed with water and dried. The crystals were purified through silica gel column chromatography and recrystallized from chloroform-methanol to give 700 mg of 7-[4-(4-chlorobenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril, m.p. 289°-291° C., colorless powders.

Provenance & Evidence