Hydrochloric Acid → HCID 178434070, compound

Participants

Reaction Steps

To a mixed solution of 5.6 g of 1,3-dimethyl-5-pyrazolone and 40 ml of dichloroethane was added 16 g of anhydrous aluminium chloride while cooling the solution by water, and 9.6 g of m-dichlorobenzene was dropwise added thereto at 30° C. Then a solution of 15.4 g of tetrachloromethane and 20 ml of dichloroethane was dropwise added to the mixed solution at 25° to 30° C. in one hour and a condensation reaction was performed at 40° C. for 90 minutes and at 50° C. for 30 minutes. The reaction mixture was allowed to cool and 100 ml of concentrated hydrochloric acid was gradually added to it and a reaction was performed at 60° to 70° C. for 4 hours. The dichloroethane solution was separated partially and refined in the same manner as in Example 1 to obtain 13.2 g of 1,3-dimethyl-4-(2,4-dichlorobenzoyl)-5-hydroxypyrazole.

Provenance & Evidence