Hydrochloric Acid → HCID 4962125, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution containing 115 g (0.50 mole) of 3,5-ditrifluoromethylphenol, 44 g (0.55 mole) of 50% aqueous sodium hydroxide and 500 ml of water, 76.4 g (0.55 mole) of bromoacetic acid in 250 ml of water neutralized with 38.7 g of potassium carbonate to pH=9 was added in one portion. The stirred reaction mixture was heated at 80°-90° C. for 24 hours. After cooling to 0° C., 60 g (0.60 mole) of concentrated hydrochloric acid in 500 ml of water was added dropwise to the solution. After stirring at 0°-10° C., the resulting solid was collected by filtration, washed with water until the washings were neutral to litmus and air-dried at 25°-30° C. A product with a melting point of 103°-104° C. was obtained in 80% yield.

Provenance & Evidence