HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → Acetanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | 2-(4'-Methoxyphenyl)-3-acetoxy-5-acetyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | HCID 13236669 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | Acetanilide | HCID 904 | 88.4% |
Reaction Steps
7-(3). The compound (VII) (200 mg) and aniline (63 mg) are added to chloroform (10 ml), and the mixture is stirred at room temperature for 2 hours. The chloroform solution is concentrated and subjected to thin layer chromatography using silica gel (developer, benzene:ethyl acetate=1:1) to give acetanilide (62 mg, 88.3%) and the title compound (II) (159 mg, 89.2%), m.p. 196°-198° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04416819 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-8efb82792a954b5a885205cad3dea883 |
| Source note | uspto-grants-1983_11 |