HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 131713227, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Methoxy-2,3,6-trimethylbenzenesulfonyl chloride | HCID 562787 | — |
| Reactant | N-[(Phenylmethoxy)carbonyl]-L-tryptophan phenylmethyl ester | HCID 14102143 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 131713227 | HCID 131713227 | — |
Reaction Steps
In the same manner as Example 5, Z-Trp-OBZl (15.0 g, 35 mM) and 4-methoxy-2,3,6-trimethylbenzenesulfonyl chloride were reacted in dichloromethane (500 ml) in the presence of sodium hydroxide (17.8 g, 0.44 M). The reaction product was then hydrolyzed with an aqueous solution of sodium hydroxide to give Z-Trp(Mtr)-OH. Yield 19.0 g (98.4%); m.p. 71°-74° C.; [α]D24 -41.6° (c=0.9, DMF).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04416820 |
| Source dataset | uspto-grants-1983_11 |
| ORD ID | ord-f3eb644de84946f8b74a3aa59c14bf55 |
| Source note | uspto-grants-1983_11 |