Phenylacetic Acid → HCID 53966216, compound

Participants

Reaction Steps

To a solution of 61 mg of 3-amino-3-methoxy-2-oxoazetidine in 2 ml of THF are added 72 mg of phenylacetic acid, 71.3 mg of 1-hydroxybenzotriazole and 130 mg of dicyclohexylcarbodiimide, and the mixture is stirred at room temperature for 3 hours. The dicyclohexylurea is filtered off, and the filtrate is concentrated. The residue is chromatographed on a column of silica gel [eluted with n-hexane-ethyl acetate (1:2)] to obtain 86 mg of 3-phenylacetamido-3-methoxy-2-oxoazetidine.

Provenance & Evidence