Phenylacetyl chloride → HCID 22824716, compound

Participants

Reaction Steps

In 2 ml of DMA is dissolved 0.28 g of the 3-(D-alaninamido)-3-methoxy-2-oxoazetidine obtained in Example 16, and 0.30 g of triethylamine is added. To the solution is added a solution of 0.233 g of phenylacetyl chloride in 2 ml of THF under ice-cooling and the mixture is stirred at room temperature for an hour. The mixture is concentrated under reduced pressure and the residue is extracted with ethyl acetate. The extract is purified by silica gel column chromatography to obtain 0.22 g of 3-(N-phenylacetyl-D-alaninamido)-3-methoxy-2-oxoazetidine.

Provenance & Evidence