Hydrochloric Acid → HCID 20479545, compound

Participants

Reaction Steps

A solution of the product from part (b) (3.10 g., 8.115 mmole) in glacial acetic acid (10 ml.) is treated with concentrated hydrochloric acid (5 ml.) and stirred at room temperature for 46 hours. The mixture is poured onto an ice-water mixture and extracted with ethyl acetate. The ethyl acetate extract is washed with water, saturated sodium chloride solution, dried over Na2SO4 and evaporated. The residue is purified by flash chromatography on silica gel (85 g.) eluting with acetic acid/methanol/dichloromethane (0.5:3.0:100) to give 470 mg. of recovered starting material and 2.0 g. of [ethoxy[1-(2-oxo-2-phenylethyl)heptyl]phosphinyl]acetic acid as a colorless glass, Rf (acetic acid/methanol/dichloromethane 0.5:5:100) 0.32.

Provenance & Evidence