反应详情

A mixture of 5.0 g (20.7 mmol) dimethyl 2,5-dimethylbenzoylphosphonate and 2.73 g (24.8 mmol) dimethyl phosphite was heated at 110° for 5 h. The excess of dimethyl phosphite and the unreacted benzoylphosphonate were removed under vacuum. The yellow viscous residue was then purified by column chromatography with chloroform as the eluent. Dimethyl α-(dimethoxyphosphinyl)2,5-dimethylbenzyl phosphate was obtained as a white oil (2.06 g, 29%); GLC and TLC analysis showed the compound to be pure.

1. temperaturewas heated at 110° for 5 h
2. customThe excess of dimethyl phosphite and the unreacted benzoylphosphonate were removed under vacuum
3. customThe yellow viscous residue was then purified by column chromatography with chloroform as the eluent