1,4-Benzodioxane-2-methanol → 2-(Chloromethyl)-2,3-dihydro-1,4-benzodioxin

Participants

Reaction Steps

A mixture of thionyl chloride (36.0 g, 0.3 mol) and 2-hydroxymethyl-1,4-benzodioxan (25.0 g, 0.15 mol) was stirred and heated under reflux for 0.75 h. The reaction mixture was concentrated under reduced pressure, and the residue was distilled, to afford 2-chloromethyl-1,4-benzodioxan, b.p. 140°-146°/22 mm Hg.

Provenance & Evidence