Acetic Acid → HCID 54274945, compound

Participants

Reaction Steps

25.7 g of 4-chloroacetoacetic acid ethyl ester, 23.9 g of 4-chlorobenzaldehyde, 0.7 ml of piperidine and 18 ml of glacial acetic acid were dissolved in 15 ml of benzene. The solution was boiled for 5 hours, using a water separator, and was allowed to cool, and 300 ml of ether were added. After the mixture had been washed three times with water, it was dried over magnesium sulphate and the solvent was evaporated off. The residue was distilled under a high vacuum. The product obtained was a Z/E mixture in a ratio of 3/1. Yield: 23.4%, boiling point 0.5: 161° to 165°.

Provenance & Evidence