Acetic Acid → HCID 86739119, compound

Participants

Reaction Steps

200 g of 4-chloroacetoacetic acid ethyl ester, 125.6 g of freshly distilled furfural, 2.6 ml of piperidine and 7 ml of glacial acetic acid were dissolved in 120 ml of benzene and the solution was boiled for 5 hours, using a water separator. 1 liter of ether was added to the cooled solution and the mixture was then extracted in each case once by shaking with saturated sodium bicarbonate solution, water, 2 M citric acid solution and again with water. After the extract had been dried over magnesium sulphate and concentrated, an oil was obtained and was subjected to incipient distillation under a high vacuum. The product remained as a viscous oil and the E/Z isomer ratio was 4:1. Yield: 86.8%.

Provenance & Evidence