Acetic Acid → HCID 54394445, compound

Participants

Reaction Steps

226.2 g of 2-trifluoromethylbenzaldehyde, 235 g of 4-chloroacetoacetic acid ethyl ester, 4.2 ml of glacial acetic acid and 2.1 ml of piperidine were dissolved in 500 ml of benzene and the solution was boiled for 8 hours using a water separator. 1 liter of ethyl acetate was added and the mixture was extracted twice with sodium bicarbonate, once with citric acid and once more with water, dried and evaporated. The crude product was subjected to incipient distillation up to 130° under a high vacuum and the product remained as the residue in the form of a chromatographically pure 2:1 isomer mixture.

Provenance & Evidence