Acetaldehyde → Ethyl 2-ethylidene-4-chloro-3-oxobutyrate

Participants

Reaction Steps

1 g of piperidine were dropped into a stirred mixture of 82 g of 4-chloroacetoacetic acid and 24 g of acetaldehyde at -20°. After stirring the mixture at -10° to -20° for 7 hours 100 ml of ethyl acetate were added and the solution was subsequently extracted three times with ice-cold 1 n hydrochloric acid and with water. The organic phase was dried over magnesium sulphate and concentrated. The oil which remained was subjected to Kugelrohr-distillation under a high vacuum.

Provenance & Evidence