Piperazine → HCID 12899687, compound

Participants

Reaction Steps

4.4 g of 8,10-dichloro-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 4.5 g of piperazine were added to 10 ml of anhydrous dimethyl sulfoxide and the mixture was heated on an oil bath at 160° to 170° C. for 7 hours while stirring. Treatment of the reaction mixture in an analogous manner as in Example 4 gave 0.9 g of 8-(1-piperazinyl)-10-chloro-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrochloride as white amorphous crystals having a melting point of 300° C. or more.

Provenance & Evidence