Piperazine → HCID 12899683, compound

Participants

Reaction Steps

18.5 g of 8-benzenesulfonyloxy-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 12.9 g of piperazine were added to 200 ml of anhydrous dimethyl sulfoxide and the mixture was heated in an autoclave under flow of nitrogen at 10 atm. at a temperature of 160° to 170° C. for 20 hours while stirring. Treatment in the same manner as in Example 15 gave 1.5 g of 8-(1-piperazinyl)-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid as white needles having a melting point of 267° to 268° C.

Provenance & Evidence